James played only 53 minutes in Tuesday's game on his return from the knee injury that ruled him out of the World Cup in Qatar, leaving him and Chelsea fearing the worst as they await a more detailed examination and prognosis.
"2022 has been the toughest year to date... It's naturally affected me mentally, I'm currently just tryna deal with the cards I've been dealt," James said on Twitter.
He underwent surgery after suffering a knee injury against AC Milan in the Champions League in October and he felt discomfort in the same knee on Tuesday.