Raleigh sent one deep off Angels' relief pitcher Jose Fermin.
He becomes just the seventh catcher in MLB history to hit at least 40 home runs in a season.
The home run also makes it the most home runs (133) by a Mariners player through their first five seasons, beating out the legendary Hall of Famer Ken Griffey Jr.
Earlier in the year, Raleigh broke the record for most home runs by a catcher before the All-Star break this season, beating out the legend Johnny Bench, while surpassing Griffey Jr. for most in Mariners history before the break.
This is now Raleigh's first 40-home run season and his third straight of hitting at least 30. After hitting just two in his debut season (2021), Raleigh went on to hit 27, 30, and 34, respectively, the next three years.
The All-Star catcher is on pace to have the greatest season by anyone at his position in MLB history.
He now needs just nine more home runs to set the single-season record (48) by a catcher previously set by the Kansas Royals' Salvador Perez, who has recently hit five home runs in five straight games.
Raleigh recently showed off why he's the true home run king this season after winning the 2025 Home Run Derby.
The 2024 Gold Glove winner is on pace to break yet another record - Aaron Judge's most home runs (62) by an American League player in a single season.
Raleigh's pace should get him to 65 on the season. He now has just 59 more games to hit 25 home runs to break the record.
Heading into Saturday night's game, Raleigh was slashing .255/.368/.609. His .987 OPS is third in all of baseball just behind Judge and Dodgers star Shohei Ohtani.