Mosimane has taken charge of six competitive internationals at home, winning three and drawing the other three, with his teams conceding only two goals in those matches.
The victories came against Niger (2-0) in 2010, Egypt (1-0) in 2011 and Guinea (2-1) in September this year, all in Africa Cup of Nations qualifiers.
There were also goalless draws against Congo in 2006 and Sierra Leone in 2011, both continental qualifiers, while Ethiopia held Bafana to a 1-1 draw in a 2014 World Cup preliminary fixture in June 2012.
That result ultimately proved Mosimane's downfall as he was sacked by the South African Football Association shortly afterwards following a disappointing run of results.
Kenya, coached by former Bafana striker Benni McCarthy, can therefore make a little history if they can upset the hosts in Soweto on Friday.
AFCON qualification
The qualification competition for the 2027 Africa Cup of Nations takes place from September 2026 to March 2027. The 48 teams have been drawn into 12 groups, with the top two in each advancing to the 24-team finals. Hosts Kenya, Tanzania and Uganda qualify automatically, but are still playing in the qualifiers; only one other team will advance from their groups.
AFCON qualifying fixtures | AFCON qualifying standings | African football news
But South Africa have proved a tough nut to crack at home under Mosimane, who has lost only once in 12 matches on South African soil across all competitions.
That was a 1-0 friendly defeat to the United States at Cape Town Stadium in November 2010.
His overall home record stands at six wins, five draws and one defeat, with his teams scoring 13 goals and conceding only four.
The results include a 2-0 friendly victory over Kenya in 2011, along with wins against Ghana (1-0) in 2010 and Burkina Faso (3-0) the following year.
Bafana are unbeaten in their last eight home matches under Mosimane, winning four and drawing four since that defeat to the Americans.
His teams have also kept eight clean sheets in 12 home fixtures, including four in six competitive internationals.
South Africa lead Group D after winning their opening two qualifiers against Guinea and Eritrea and will be seeking another three points against Kenya before travelling to Nairobi for the return fixture on Tuesday.