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The opening round of matches in the 2026/27 UEFA Champions League continues Wednesday evening, with six more games on the schedule.
Followers will see some potential champions in action, including Barcelona, Liverpool, and three-in-a-row-chasing PSG.
With every match streamed live and major sportsbooks offering pregame betting, there's plenty to keep you entertained.
Browse our list of online betting partners, sign up with your favorite, and lock in a welcome bonus free bet ahead of kickoff.
On this page, experienced soccer betting writer Frank Monkhouse walks you through his Napoli v Arsenal preview and predictions. Each pick is led by the latest stats and trends available now on the Flashscore app and website.
Napoli v Arsenal betting tips
Arsenal or draw: -550 (FanDuel) | -525 (BetMGM)
Under 3.5 goals: -310 (FanDuel) | -325 (BetMGM)
De Bruyne shot on target: -105 (FanDuel) | +115 (BetMGM)
The odds, correct at the time of publication, are subject to change.
Double chance - Arsenal or draw
My first of three suggested bets at the iconic Stadio Diego Armando Maradona is on the English Premier League side to avoid defeat.
When betting on the moneyline market, you have a one-in-three chance of making a profit. Your pick works against the draw and the opponent. When using the double chance betting market, you have a two-in-three chance of beating the sportsbooks.
You'll boost your bankroll if Arsenal beats Napoli or the night ends in a draw. A thrilling 3-0 victory for the Gunners is just as good as a scoreless 0-0 tie.
Head-to-head stats on the Flashscore app show Napoli and Arsenal have met four times previously. Interestingly, Arsenal has won all but one of those games, with Napoli taking the lone win back in 2013.
In the most recent encounters, the Italians and English sides played home and away in 2019. Arsenal won 2-0 in London, and 1-0 in Naples. It’s also worth knowing that the Brits kept a clean sheet in each of the three wins mentioned.
You may remember that Arsenal were the only team in last season’s UCL to avoid defeat in regulation time. Mikel Arteta’s Premier League champions won 11 and drew four. They face a tough opener on Italian soil, but I'm confident it won't be a wasted trip.
Bet on Arsenal to take at least a point from this matchup. The odds offered on this wager make it perfect for midweek parlays and Napoli vs. Arsenal same-game parlays.
Arsenal or draw: -550 (FanDuel) | -525 (BetMGM)
Bet explanation: You'll make a profit on this match with any result other than a win for the home team.
Total goals - Under 3.5
Moving away from predicting the winning team, I head into the ever-popular total goals market.
Back Napoli vs Arsenal to produce fewer than four goals. The winning team, scorers, and time of the goals don’t matter too much here. If Wednesday’s match ends with three goals or less, you’ll be celebrating a profit.
Sticking with the H2H for now, we see that a bet on under 3.5 goals landed in each of the previous four meetings. Those matches finished 2-0, 2-0, 2-0, and 1-0.
Napoli have played three games in the Italian Serie A, with under 3.5 goals proving a winning bet twice. In the Premier League, Arsenal have beaten Chelsea 2-1, Aston Villa 1-0, and Coventry City 3-0.
Arsenal impressed everyone who watched their run to last season's Champions League final, especially on defense. Despite playing 15 games, the North London club allowed the fewest goals of any team, conceding just 7.
Arsenal's xG allowed per game was no higher than 0.9, also the lowest total of any team in the competition.
Need more convincing before risking your wager? I've got you covered.
Arsenal goalkeeper David Raya posted a clean sheet in 53% of his starts in this tournament. That's better than any other Champions League goalkeeper who has played at least 25 games.
Arteta and his coaching staff know that to stand any chance of taking three points back to London, they need a strong, reliable defense.
Under 3.5 goals: -310 (FanDuel) | -325 (BetMGM)
Bet explanation: Napoli v Arsenal must end with fewer than four goals scored by both teams combined.
1+ shots on target - De Bruyne
I'll round off my three Napoli vs Arsenal Champions League predictions with a pick at slightly higher odds. You can play this one as a single bet or add it to a small parlay.
Here, we're backing Napoli's Kevin De Bruyne to record at least one shot on target during Wednesday evening's match.
It doesn't matter if the 35-year-old ex-Chelsea and Manchester City midfielder scores a stunning strike or his tame effort rolls right back to the visiting goalkeeper. If De Bruyne gets a shot on target, your bet wins.
I was thrilled with the odds available on De Bruyne 1+ shots on target. Expecting something in the range of -200 or -225, I was pleasantly surprised to see bet365 offering -110. That's too good to pass up, and it's a bet that stays live for as long as Kevin is on the field.
Soccer fans and Premier League followers know De Bruyne has plenty of experience against Arsenal. The Belgian has been directly involved in a dozen goals across his previous 17 meetings with the Gunners in all competitions.
Eight goals and four assists, including five in his last three games against Arsenal, make for pleasant reading. However, it's important to remember that bettors don't need De Bruyne to score — just to record a shot on target.
De Bruyne 1+ shots on target:-105 (FanDuel) | +115 (BetMGM)
Bet explanation: Kevin De Bruyne must get a shot on target at any stage of the match against Arsenal.
Napoli vs Arsenal betting odds
Napoli win: +390 (FanDuel) | +360(BetMGM)
Draw: +260 (FanDuel) | +270 (BetMGM)
Arsenal win: -140 (FanDuel) | -135 (BetMGM)
This article contains affiliate links to advertisers. The analysis is our own. Age, location and other restrictions apply. Please play responsibly