Plea, 33, missed most of last season after sustaining a severe knee injury in the away game at FC Twente in August.
The Frenchman sustained a new injury during Thursday's training session, which was unrelated to Plea's previous injury. PSV confirm Plea will be absent at least until the next international break in late September.
“I’m staying determined and will do everything I can to be back as soon as possible,” Plea said on the club website.
“It’s not about how often you fall down, but how often you get back up.”
Alassane Plea joined PSV from Borussia Monchengladbach in 2025. The Frenchman has made just four appearances for PSV.
Flashscore covers the 2026/27 Eredivisie season week in, week out, with match reports and daily roundups. From PSV's title defence to Telstar's relegation fight and Ajax's resurrection. Flashscore's Paul Winters delivers the Eredivisie Team of the Week every Monday and looks back on the past weekend in his weekly ErediVision column.
Latest news | Competition standings | Latest results | Upcoming fixtures