Messi became the first player to win back-to-back MLS MVP awards and only the second MLS player to capture two MVP awards after Preki in 1997 and 2003.
"I'm happy to receive this award and be the first in the history of this league to win it in two consecutive years," Messi said. "I'm very thankful."
The 38-year-old forward, who led Argentina to the 2022 World Cup crown, scored 29 goals in the regular season and set up 19 others to claim the MLS Golden Boot.
Messi, who signed a three-year contract extension with Miami in October, also became only the second player to lead the league in regular-season goals and assists, joining Toronto's Sebastian Giovinco in 2015.
Messi also netted six goals and assisted on nine others in this year's MLS playoffs, which concluded last weekend with Inter Miami beating Vancouver 3-1 for its first MLS Cup title, Messi delivering two key assists in the triumph to claim MLS Cup MVP honors.
It's the latest award in a trophy haul for the South American maestro that includes a record eight Ballon d’Or titles, three FIFA Men's Best Player awards and two FIFA World Cup Golden Balls.
Messi has also captured three UEFA Men's Player of the Year awards, six European Golden Shoes, six La Liga Best Player awards and has been named Argentina's Footballer of the Year 15 times.